Loss of allelic heterozygosity at the harvey ras locus in human oral carcinomas.

doi:10.1007/BF01612771

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Article

Loss of allelic heterozygosity at the harvey ras locus in human oral carcinomas.

Journal of cancer research and clinical oncology - 1 Jan 1991

Saranath D, Bhoite L T, Mehta A R, Sanghavi V, Deo M G

Abstract excerpt

The Harvey ras locus was examined for restriction fragment polymorphism and loss of allelic heterozygosity in 62 oral cancer patients. Southern blot analysis on BamHI digests of the tumour tissue DNA, revealed 23 patients with H-ras-1 heterozygosity. The probes used to study the polymorphism were the BamHI 6.6-kb fragment encoding the complete H-ras-1 sequence plus the variable tandem repeat (VTR) region, and the...

Topics

Adult
Aged
Alleles
Carcinoma, Squamous Cell
DNA
Deoxyribonuclease BamHI
Deoxyribonucleases, Type II Site-Specific
Female
Gene Rearrangement
Genes, ras
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Mouth Neoplasms

Polymorphism, Restriction Fragment Length

Repetitive Sequences, Nucleic Acid

Site-Specific DNA-Methyltransferase (Adenine-Specific)

Source

Open in PubMed

Identifiers

PMID: 1679760
DOI: 10.1007/BF01612771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1679760-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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