Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes.

Article

Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1993

Schuetz J D, Schuetz E G

Abstract excerpt

Previous studies reported that, in the absence of drug exposure, multidrug resistance, including resistance to Adriamycin (ADR), could develop in primary rat hepatocyte cultures (B. Carr, Proc. Am. Assoc. Cancer Res., 29:1158, 1988). However, the hepatocytes in that report were cultured on plasti...

Topics

Animals
Cells, Cultured
Doxorubicin
Drug Resistance
Extracellular Matrix
Gene Expression Regulation
Liver
Phenotype
Rats

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