Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.

doi:10.1128/mcb.10.6.3224-3231.1990

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Article

Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.

Molecular and cellular biology - 1 Jun 1990

Kim S, Humphries E H, Tjoelker L, Carlson L, Thompson C B

Abstract excerpt

The chicken immunoglobulin light-chain gene (IgL) encodes only a single variable gene segment capable of recombination. To generate an immune repertoire, chickens diversify this unique rearranged VL gene segment during B-cell development in the bursa of Fabricius. Sequence analysis of IgL cDNAs suggests that both gene conversion events derived from VL segment pseudogene templates (psi VL) and non-template-derived...

Topics

Alleles
Animals
Base Sequence
Cell Line
Chickens
Clone Cells
DNA, Neoplasm
Gene Conversion
Gene Rearrangement
Genes, Immunoglobulin
Immunoglobulin Joining Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Light Chains

Immunoglobulin Variable Region

Lymphoma

Molecular Sequence Data

Rats

Restriction Mapping

Templates, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2111450
DOI: 10.1128/mcb.10.6.3224-3231.1990
PMCID: PMC360687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2111450-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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