Two closely related kappa variable region pseudogenes pose an evolutionary paradox.

doi:10.1007/BF00211995

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Article

Two closely related kappa variable region pseudogenes pose an evolutionary paradox.

Immunogenetics - 1 Jan 1991

Chung D A, Gibson D M

Abstract excerpt

Two pseudogenes belonging to the Igk-V1 variable region group have been isolated from BALB/c mice. The genes share greater than 96.5% identity of nucleotide sequence in a 1800 base pair (bp) region surrounding the coding region, but deletions of 221 bp and 84 bp have removed essential sequences from the two genes. As the deletions are different in the two pseudogenes, they must have occurred independently in each...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
DNA Probes
Electrophoresis, Polyacrylamide Gel
Gene Library
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred AKR

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1682245
DOI: 10.1007/BF00211995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1682245-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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