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Article

Growth hormone promotes glomerular lipid accumulation in bGH mice.

Kidney international - 1 Nov 2005

Machado Marcos O, Hirata Rosario D C, Sellitti Donald F, Iotti Roberto, Iotti Alejandro, Cusumano Ana M, Riordan Gavin P, Coschigano Karen T, Kopchick John J, Zuhl Irina, Nguyen Nga, Hirata Mario H, Doi Sonia Q

Abstract excerpt

BACKGROUND: Bovine growth hormone (bGH) transgenic mice develop progressive glomerulosclerosis and exhibit abnormalities in hepatic lipid metabolism. We have previously shown that growth hormone up-regulates the low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in mouse mesangial cells. However, a role of lipid abnormalities in bGH kidney disease has not yet been...

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Identifiers

PMID: 16221202
DOI: 10.1111/j.1523-1755.2005.00656.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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