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Article

Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.

Journal of virology - 1 Dec 2010

Steidle Sabine, Martínez-Sobrido Luis, Mordstein Markus, Lienenklaus Stefan, García-Sastre Adolfo, Stäheli Peter, Kochs Georg

Abstract excerpt

The nonstructural protein NS1 of influenza A virus counteracts the interferon (IFN) system and thereby promotes viral replication. NS1 has acquired different mechanisms to limit induction of IFN. It prevents double-stranded RNA (dsRNA) and RIG-I-mediated activation of interferon regulatory factor 3 (IRF3), and it blocks posttranscriptional processing of cellular mRNAs by binding to the cleavage and...

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Identifiers

PMID: 20926573
DOI: 10.1128/JVI.00701-10
PMCID: PMC3004359

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Source receipt: pubmed, retrieved 7 Sept 2026.

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