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H9N2 Influenza Virus Infections in Human Cells Require a Balance between Neuraminidase Sialidase Activity and Hemagglutinin Receptor Affinity.

Journal of virology - 31 Aug 2020

Arai Yasuha, Elgendy Emad Mohamed, Daidoji Tomo, Ibrahim Madiha Salah, Ono Takao, Sriwilaijaroen Nongluk, Suzuki Yasuo, Nakaya Takaaki, Matsumoto Kazuhiko, Watanabe Yohei

Abstract excerpt

Some avian influenza (AI) viruses have a deletion of up to 20 to 30 amino acids in their neuraminidase (NA) stalk. This has been associated with changes in virus replication and host range. Currently prevalent H9N2 AI viruses have only a 2- or 3-amino-acid deletion, and such deletions were detected in G1 and Y280 lineage viruses, respectively. The effect of an NA deletion on the H9N2 phenotype has not been fully...

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Share to Hemagglutinin Glycoproteins, Influenza Virus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza A Virus, H9N2 Subtype

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Identifiers

PMID: 32641475
DOI: 10.1128/JVI.01210-20
PMCID: PMC7459563

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