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Article

Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses.

Scientific reports - 7 Sept 2017

Park Sehee, Il Kim Jin, Lee Ilseob, Bae Joon-Yong, Yoo Kirim, Nam Misun, Kim Juwon, Sook Park Mee, Song Ki-Joon, Song Jin-Won, Kee Sun-Ho, Park Man-Seong

Abstract excerpt

It has been noticed that neuraminidase (NA) stalk truncation has arisen from evolutionary adaptation of avian influenza A viruses (IAVs) from wild aquatic birds to domestic poultry. We identified this molecular alteration after the adaptation of a 2009 pandemic H1N1 virus (pH1N1) in BALB/c mice. The mouse-adapted pH1N1 lost its eight consecutive amino acids including one potential N-linked glycosite from the NA...

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Identifiers

PMID: 28883554
DOI: 10.1038/s41598-017-11348-0
PMCID: PMC5589767

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