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Article

Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice.

Journal of virology - 1 May 2009

Matsuoka Yumiko, Swayne David E, Thomas Colleen, Rameix-Welti Marie-Anne, Naffakh Nadia, Warnes Christine, Altholtz Melanie, Donis Ruben, Subbarao Kanta

Abstract excerpt

Following circulation of avian influenza H5 and H7 viruses in poultry, the hemagglutinin (HA) can acquire additional glycosylation sites, and the neuraminidase (NA) stalk becomes shorter. We investigated whether these features play a role in the pathogenesis of infection in mammalian hosts. From...

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Source

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Identifiers

PMID: 19225004
DOI: 10.1128/JVI.01987-08
PMCID: PMC2668507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19225004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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