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Article

Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice.

Journal of virology - 1 Mar 2013

Sun Yipeng, Tan Yuanyuan, Wei Kai, Sun Honglei, Shi Yi, Pu Juan, Yang Hanchun, Gao George F, Yin Yanbo, Feng Wenhai, Perez Daniel R, Liu Jinhua

Abstract excerpt

H9N2 influenza viruses with an A316S substitution in hemagglutinin (HA) and a shorter neuraminidase (NA) stalk have become predominant in China. The A316S was shown to increase HA cleavage efficiency when combined with short stalk NA, and the short stalk NA improved NA enzyme activity and release of virus from erythrocytes. Single mutations or combinations of these mutations strengthened the virulence of H9N2...

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Identifiers

PMID: 23269805
DOI: 10.1128/JVI.02688-12
PMCID: PMC3571412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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