Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene.

Article

Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene.

The Journal of biological chemistry - 11 Mar 1994

Papadopoulou B, Roy G, Mourad W, Leblanc E, Ouellette M

Abstract excerpt

The short chain dehydrogenase gene ltdh, which is derived from the H locus of Leishmania, confers high level resistance to the dihydrofolate reductase inhibitor methotrexate via a novel mechanism. Resistance is correlated with LTDH overproduction. High level resistance of ltdh transfectants was o...

Topics

Animals
Diploidy
Folic Acid
Genes, Protozoan
Leishmania
Mutation
Oxidoreductases
Phenotype
Pterins
Transfection

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