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Article

Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene.

The Journal of biological chemistry - 11 Mar 1994

Papadopoulou B, Roy G, Mourad W, Leblanc E, Ouellette M

Abstract excerpt

The short chain dehydrogenase gene ltdh, which is derived from the H locus of Leishmania, confers high level resistance to the dihydrofolate reductase inhibitor methotrexate via a novel mechanism. Resistance is correlated with LTDH overproduction. High level resistance of ltdh transfectants was observed even in poor media where reduced folates are essential for the synthesis of thymidylate precursors. The ltdh...

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PMID: 8125946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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