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Article

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity.

Oncogene - 1 Nov 1993

Tarunina M, Jenkins J R

Abstract excerpt

Wild-type human p53 protein is able to self-associate and consists predominantly of homotetramers in solution. In earlier work we identified the protein sequence motifs involved in p53 quaternary structure and showed that while monomeric p53 protein retains tumour suppressor function, monomeric tumour mutant p53 lacks dominant transforming activity. In this report we use point mutated and truncated cDNA genes...

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Identifiers

PMID: 8414520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity.PMID 8414520Read ↗

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