Article
Structural evolution of p53, p63, and p73: implication for heterotetramer formation.
Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2009
Joerger Andreas C, Rajagopalan Sridharan, Natan Eviatar, Veprintsev Dmitry B, Robinson Carol V, Fersht Alan R
Abstract excerpt
Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development. To elucidate the molecular basis for tetramer formation of the various family members, we solved the crystal structure of the human p73 tetramerization domain (residues 351-399). Similarly to the canonical p53 tetramer, p73 forms a tetramer with...
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