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Article

Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B.

Nature - 30 Sept 1993

Kerr L D, Ransone L J, Wamsley P, Schmitt M J, Boyer T G, Zhou Q, Berk A J, Verma I M

Abstract excerpt

The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the kappa B site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between kappa B enhancer binding proteins and basal...

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Source

Identifiers

PMID: 8413585
DOI: 10.1038/365412a0

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B.PMID 8413585Read ↗

The Drosophila TATA binding protein contains a strong but masked activation domain.Semantic proximity Read ↗

An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation.Semantic proximity Read ↗

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Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110.Semantic proximity Read ↗

Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y.Semantic proximity Read ↗

Both Jun and Fos contribute to transcription activation by the heterodimer.Semantic proximity Read ↗

Interaction of the viral activator protein ICP4 with TFIID through TAF250.Semantic proximity Read ↗

Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain.Semantic proximity Read ↗

Complex interactions between yeast TFIIIB and TFIIIC.Semantic proximity Read ↗

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