Article
Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110.
Mechanisms of development - 1 Jun 1999
Pham A D, Müller S, Sauer F
Abstract excerpt
In Drosophila, a coordinate interplay between the Rel transcription factor Dorsal and the basic Helix-Loop-Helix transcription factor Twist initiates mesoderm formation by activating the zygotic expression of mesoderm-determining genes. Here, we show that TBP-associated-factors (TAF(II)s) within the basal transcription factor TFIID mediate transcriptional activation by Dorsal and Twist. Dorsal interacts with...
Topics
- Animals
- Cell Differentiation
- Cell-Free System
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Gene Dosage
- Gene Expression Regulation, Developmental
- Histone Acetyltransferases
- Mesoderm
- Mutation
- Nuclear Proteins
- Phosphoproteins