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Article

Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110.

Mechanisms of development - 1 Jun 1999

Pham A D, Müller S, Sauer F

Abstract excerpt

In Drosophila, a coordinate interplay between the Rel transcription factor Dorsal and the basic Helix-Loop-Helix transcription factor Twist initiates mesoderm formation by activating the zygotic expression of mesoderm-determining genes. Here, we show that TBP-associated-factors (TAF(II)s) within the basal transcription factor TFIID mediate transcriptional activation by Dorsal and Twist. Dorsal interacts with...

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Source

Identifiers

PMID: 10473116
DOI: 10.1016/s0925-4773(99)00051-9

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110.PMID 10473116Read ↗

TAFII mutations disrupt Dorsal activation in the Drosophila embryo.Semantic proximity Read ↗

Developmental and transcriptional consequences of mutations in Drosophila TAF(II)60.Semantic proximity Read ↗

TAF(II)s mediate activation of transcription in the Drosophila embryo.Semantic proximity Read ↗

Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.Semantic proximity Read ↗

Two Novel <i>Drosophila</i> TAF<sub>II</sub>s Have Homology with Human TAF<sub>II</sub>30 and Are Differentially Regulated during DevelopmentSemantic proximity Read ↗

TAF10 and TAF10b partially redundant roles during Drosophila melanogaster morphogenesis.Semantic proximity Read ↗

Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities.Semantic proximity Read ↗

TAF250 is required for multiple developmental events in Drosophila.Semantic proximity Read ↗

p53 Transcriptional Activation Mediated by Coactivators TAF <sub>II</sub> 40 and TAF <sub>II</sub> 60Semantic proximity Read ↗

Genome-wide identification of Tribolium dorsoventral patterning genes.Semantic proximity Read ↗

twist and snail as positive and negative regulators during Drosophila mesoderm development.Semantic proximity Read ↗

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