Deleting two amino acids in glycoprotein gI of pseudorabies virus decreases virulence and neurotropism for pigs, but does not affect immunogenicity.

doi:10.1099/0022-1317-74-10-2201

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Article

Deleting two amino acids in glycoprotein gI of pseudorabies virus decreases virulence and neurotropism for pigs, but does not affect immunogenicity.

The Journal of general virology - 1 Oct 1993

Jacobs L, Mulder W A, Van Oirschot J T, Gielkens A L, Kimman T G

Abstract excerpt

The virulence, pathogenicity and immunogenicity of two pseudorabies virus (PRV) variants were investigated in 3-week-old pigs that had been intranasally infected. Variant M303 (delta 125,126) lacked amino acids valine (125) and cysteine(126) in an immunodominant antigenic region of glycoprotein I...

Topics

Amino Acids
Animals
Cell Line
Herpesvirus 1, Suid
Mutation
Oropharynx
Pseudorabies
Swine
Swine Diseases
Viral Envelope Proteins
Virulence

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