Article
A comparative study of pseudorabies virus (PRV) strains with defects in thymidine kinase and glycoprotein genes.
Journal of comparative pathology - 1 Jan 2000
Ferrari M, Mettenleiter T C, Romanelli M G, Cabassi E, Corradi A, Dal Mas N, Silini R
Abstract excerpt
In the course of two experiments, an examination was made of the virulence and neuroinvasiveness for pigs of two pseudorabies virus mutants (strain 6C2TK(-), with a defect in thymidine kinase (TK) function; and strain 6C2TK(-), gI(-)/gE(-), with defects in TK and glycoproteins I and E) and of the wild-type parent strain (86/27V). At various times after intranasal inoculation, pigs were killed and samples of...
Topics
- Animals
- Antibodies, Viral
- Antigens, Viral
- Cell Line
- Central Nervous System
- DNA, Viral
- Dexamethasone
- Herpesvirus 1, Suid
- Immunohistochemistry
- Mutation
- Olfactory Bulb