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Article

The mutations on the envelope glycoprotein D contribute to the enhanced neurotropism of the pseudorabies virus variant.

The Journal of biological chemistry - 1 Nov 2023

Wu Hongxia, Qi Hansong, Wang Bing, Li Mingzhi, Qu Liang, Li Su, Luo Yuzi, Li Lian-Feng, Zheng Guang-Lai, Qiu Hua-Ji, Sun Yuan

Abstract excerpt

The pseudorabies virus (PRV) TJ strain, a variant of PRV, induces more severe neurological symptoms and higher mortality in piglets and mice than the PRV SC strain isolated in 1980. However, the mechanism underlying responsible for the discrepancy in virulence between these strains remains unclear. Our study investigated the differences in neurotropism between PRV TJ and PRV SC using both in vitro and in vivo...

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Source

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Identifiers

PMID: 37838171
DOI: 10.1016/j.jbc.2023.105347
PMCID: PMC10652121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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