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Article

The immunogenicity of PRV ΔgE/TK/UL49.5 three-gene-deleted vaccine in mice

4 Feb 2025

Abstract excerpt

BACKGROUND: Pseudorabies (PR) caused by the re-emerging of pseudorabies virus (PRV) variant has outbroken among PRV vaccine immunized swine in many pig farms, which has caused serious social and economic consequences since the end of 2011. The PRV UL49.5 protein can inactivate the transporter associated with antigen processing (TAP), thereby downregulating the cell surface expression of swine leukocyte antigen...

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PMID: 39905542
DOI: 10.1186/s12985-025-02641-w

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