Article
Inactivation of the thymidine kinase gene of a gI deletion mutant of pseudorabies virus generates a safe but still highly immunogenic vaccine strain.
The Journal of general virology - 1 Jul 1990
Moormann R J, de Rover T, Briaire J, Peeters B P, Gielkens A L, van Oirschot J T
Abstract excerpt
In an earlier report, we described the construction of the genetically engineered pseudorabies virus strain 2.4N3A which does not express glycoprotein gI. Although this strain showed a strongly reduced virulence in 10-week-old seronegative pigs, it could still cause severe disease or death in 3-d...
Topics
- Animals
- Base Sequence
- Cell Line
- Chromosome Deletion
- DNA, Viral
- Genes, Viral
- Herpesvirus 1, Suid
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Restriction Mapping
- Swine
- Thymidine Kinase
- Viral Structural Proteins
- Viral Vaccines