Glycoprotein D-negative pseudorabies virus can spread transneuronally via direct neuron-to-neuron transmission in its natural host, the pig, but not after additional inactivation of gE or gI.

doi:10.1128/JVI.70.4.2191-2200.1996

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Article

Glycoprotein D-negative pseudorabies virus can spread transneuronally via direct neuron-to-neuron transmission in its natural host, the pig, but not after additional inactivation of gE or gI.

Journal of virology - 1 Apr 1996

Mulder W, Pol J, Kimman T, Kok G, Priem J, Peeters B

Abstract excerpt

Envelope glycoprotein D (gD) is essential for entry of pseudorabies virus (PRV) into cells but is not required for the subsequent steps in virus replication. Phenotypically complemented gD mutants can infect cells and can spread, both in vitro and in mice, by direct cell-to-cell transmission. Pro...

Topics

Animals
Antigens, Viral
Base Sequence
Cell Line
Female
Herpesvirus 1, Suid
Male
Molecular Sequence Data
Mutagenesis
Neurons
Olfactory Nerve
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pseudorabies

Swine

Swine Diseases

Trigeminal Ganglion

Viral Envelope Proteins

Virulence

Source

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Identifiers

PMID: 8642642
DOI: 10.1128/JVI.70.4.2191-2200.1996
PMCID: PMC190058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8642642-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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