Article
Safety of an Aujeszky's disease vaccine based on deletion mutant strain 783 which does not express thymidine kinase and glycoprotein I.
The Veterinary record - 3 Nov 1990
van Oirschot J T, Terpstra C, Moormann R J, Berns A J, Gielkens A L
Abstract excerpt
The safety of an Aujeszky's disease virus vaccine based on strain 783, a deletion mutant which does not express glycoprotein I and thymidine kinase, was assessed in pigs, calves and sheep. Four-day-old piglets which were inoculated intranasally and intramuscularly with 10(7) plaque forming units (PFU) developed only slight depression and fever. The virus was transmitted to a sentinel piglet. Six weeks after...
Topics
- Administration, Intranasal
- Animals
- Antibodies, Viral
- Chromosome Deletion
- Female
- Herpesvirus 1, Suid
- Injections, Intramuscular
- Mutation
- Pseudorabies
- Specific Pathogen-Free Organisms