Article
Glycoprotein I of pseudorabies virus (Aujeszky's disease virus) determines virulence and facilitates penetration of the virus into the central nervous system of pigs.
Acta veterinaria Hungarica - 1 Jan 1994
Jacobs L, Mulder W A, Priem J, Pol J M, Kimman T G
Abstract excerpt
In the present study we investigated the virulence and neural spread of pseudorabies virus (PRV) strains with mutations in the gene encoding glycoprotein I (gI) in 3-week-old pigs which were intranasally infected. Mutant M303 (lambda 125, 126) lacks amino acids valine-125 and cysteine-126 in an i...
Topics
- Animals
- Brain
- Brain Diseases
- Cell Line
- Cells, Cultured
- Herpesvirus 1, Suid
- Kidney
- Mutation
- Oropharynx
- Pseudorabies
- Swine
- Swine Diseases
- Trigeminal Ganglion
- Viral Envelope Proteins
- Virulence
- Virus Replication