Article
Non-transmissible pseudorabies virus gp50 mutants: a new generation of safe live vaccines.
Vaccine - 1 Mar 1994
Peeters B, Bouma A, de Bruin T, Moormann R, Gielkens A, Kimman T
Abstract excerpt
Envelope glycoprotein gp50 of pseudorabies virus (PRV) is essential for virus entry, but is not required for subsequent steps in the viral replication cycle. Phenotypically-complemented gp50 null mutants can infect cells and can spread, both in vitro and in vivo, by direct cell-to-cell transmissi...
Topics
- Animals
- Antibodies, Viral
- Cell Line
- Herpesvirus 1, Suid
- Lymphocyte Activation
- Mutation
- Neutralization Tests
- Pseudorabies
- Swine
- Swine Diseases
- Vaccines, Attenuated
- Viral Envelope Proteins
- Viral Vaccines