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Article

Non-transmissible pseudorabies virus gp50 mutants: a new generation of safe live vaccines.

Vaccine - 1 Mar 1994

Peeters B, Bouma A, de Bruin T, Moormann R, Gielkens A, Kimman T

Abstract excerpt

Envelope glycoprotein gp50 of pseudorabies virus (PRV) is essential for virus entry, but is not required for subsequent steps in the viral replication cycle. Phenotypically-complemented gp50 null mutants can infect cells and can spread, both in vitro and in vivo, by direct cell-to-cell transmission. However, progeny virions released by the infected cells are non-infectious because they lack gp50. Therefore, these...

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Source

Identifiers

PMID: 8178562
DOI: 10.1016/0264-410x(94)90104-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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