Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.

doi:10.1093/emboj/16.9.2205

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Article

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.

The EMBO journal - 1 May 1997

Bömer U, Meijer M, Maarse A C, Hönlinger A, Dekker P J, Pfanner N, Rassow J

Abstract excerpt

The protein transport machinery of the inner mitochondrial membrane contains three essential Tim proteins. Tim17 and Tim23 are thought to build a preprotein translocation channel, while Tim44 transiently interacts with the matrix heat shock protein Hsp70 to form an ATP-driven import motor. For this report we characterized the biogenesis and interactions of Tim proteins. (i) Import of the precursor of Tim44 into...

Topics

Adenosine Triphosphate
Biological Transport
Calcium-Transporting ATPases
Carrier Proteins
Fungal Proteins
HSP70 Heat-Shock Proteins
Intracellular Membranes
Macromolecular Substances
Membrane Proteins
Membrane Transport Proteins
Mitochondria
Mitochondrial Membrane Transport Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondrial Precursor Protein Import Complex Proteins

Molecular Chaperones

Phenotype

Precipitin Tests

Protein Binding

Protein Precursors

Source

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Identifiers

PMID: 9171336
DOI: 10.1093/emboj/16.9.2205
PMCID: PMC1169823

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