Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States.

doi:10.1016/0016-5085(93)90964-e

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Article

Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States.

Gastroenterology - 1 Oct 1993

Laskus T, Persing D H, Nowicki M J, Mosley J W, Rakela J

Abstract excerpt

BACKGROUND: A precore defective hepatitis B virus (HBV) mutant unable to produce hepatitis B e antigen (HBeAg) has been associated with fulminant hepatitis B. We have studied the etiologic contribution of precore mutants among North American patients with this disorder. METHODS: We studied 39 pat...

Topics

Adenine
Adolescent
Adult
Aged
Aged, 80 and over
Base Sequence
DNA, Viral
Female
Gene Amplification
Guanine
Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation

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