Article
Overexpression of human loricrin in transgenic mice produces a normal phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1993
Yoneda K, Steinert P M
Abstract excerpt
The cornified cell envelope (CE) of terminally differentiating stratified squamous epithelial cells is a complex multiprotein assembly about 15 nm thick of which loricrin is a major component. We have produced transgenic mice bearing the human loricrin transgene in order to study the role of lori...
Topics
- Age Factors
- Animals
- Base Sequence
- Calcium
- Cell Differentiation
- Cloning, Molecular
- DNA Primers
- Epidermis
- Epithelium
- Gene Expression
- Genes
- Humans
- Immunohistochemistry
- Membrane Proteins
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Phenotype