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Article

Overexpression of human loricrin in transgenic mice produces a normal phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1993

Yoneda K, Steinert P M

Abstract excerpt

The cornified cell envelope (CE) of terminally differentiating stratified squamous epithelial cells is a complex multiprotein assembly about 15 nm thick of which loricrin is a major component. We have produced transgenic mice bearing the human loricrin transgene in order to study the role of loricrin in CE assembly, structure, and function. By analyses of RNA and protein, we show that the human transgene is...

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Identifiers

PMID: 8248167
DOI: 10.1073/pnas.90.22.10754
PMCID: PMC47856

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Overexpression of human loricrin in transgenic mice produces a normal phenotype.PMID 8248167Read ↗

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A novel c.545-546insG mutation in the loricrin gene correlates with a heterogeneous phenotype of loricrin keratoderma.Semantic proximity Read ↗

A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome.Semantic proximity Read ↗

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