Article
Complement lytic activity has no role in the pathogenesis of autoimmune diabetes in NOD mice.
Diabetes - 1 Nov 1993
Baxter A G, Cooke A
Abstract excerpt
The NOD mouse is widely used as a model of organ-specific autoimmunity because it develops specific autoimmune destruction of pancreatic beta-cells. Although it is clear that T-cells and monocytes are necessary for beta-cell destruction, humoral factors, such as antibodies and complement, may also contribute to tissue damage. Attempts to cure diabetes in experimental models by immunoisolation of transplanted...
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