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Article

Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin.

Diabetes - 1 Sept 2010

Lin Marvin, Yin Na, Murphy Barbara, Medof M Edward, Segerer Stephan, Heeger Peter S, Schröppel Bernd

Abstract excerpt

OBJECTIVE: The complement system contributes to autoimmune injury, but its involvement in promoting the development of autoimmune diabetes is unknown. In this study, our goal was to ascertain the role of complement C3 in autoimmune diabetes. RESEARCH DESIGN AND METHODS: Susceptibility to diabetes development after multiple low-dose streptozotocin treatment in wild-type (WT) and C3-deficient mice was analyzed....

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Source

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Identifiers

PMID: 20584999
DOI: 10.2337/db10-0044
PMCID: PMC2927947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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