Article
Failure of exogenously administered interferon-gamma or blockage of endogenous interleukin-4 with specific inhibitors to augment the incidence of autoimmune diabetes in male NOD mice.
Autoimmunity - 1 Jan 1999
Xiang M, Zaccone P, Di Marco R, Harris R, Magro G, Di Mauro M, Meroni P L, Garotta G, Nicoletti F
Abstract excerpt
Interferon (IFN)-gamma and interleukin (IL)-4 are prototypic type 1 and type 2 cytokines which are known to play pathogenetic and protective roles, respectively, in NOD mouse IDDM. The capacity of male NOD mice to produce more IL-4 and less IFN-gamma within the insulitic lesions than females has been suggested to contribute to their lower incidence of diabetes. In this study we have tested the effects of...
Topics
- Animals
- Antibodies, Monoclonal
- Autoantibodies
- Autoantigens
- Autoimmune Diseases
- CHO Cells
- Cricetinae
- Cyclophosphamide
- Diabetes Mellitus, Type 1
- Female
- Genetic Predisposition to Disease
- Immunoglobulin E
- Immunoglobulin G