Mutations induced by (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells.

doi:10.1002/em.10136

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Mutations induced by (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells.

Environmental and molecular mutagenesis - 1 Jan 2003

Mahadevan Brinda, Dashwood Wan-Mohaiza, Luch Andreas, Pecaj Arta, Doehmer Johannes, Seidel Albrecht, Pereira Cliff, Baird William M

Abstract excerpt

The polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene (DB[a,l]P) is an exceptionally potent carcinogen. Its direct DNA-reactive metabolite, the fjord region (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide [(-)-anti-DB[a,l]PDE], was used to investigate induction of mutations in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells. Cells exposed to 1-10 nM...

Topics

Animals
Antimetabolites, Antineoplastic
Benzopyrenes
Cell Division
Cells, Cultured
Cricetinae
DNA Adducts
DNA Primers
DNA, Complementary
Epoxy Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exons

Gene Deletion

Hypoxanthine Phosphoribosyltransferase

Mutation

Polymerase Chain Reaction

Thioguanine

Source

Open in PubMed

Identifiers

PMID: 12605383
DOI: 10.1002/em.10136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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