Article
Dependence on p75 for innervation of some sympathetic targets.
Science (New York, N.Y.) - 11 Mar 1994
Lee K F, Bachman K, Landis S, Jaenisch R
Abstract excerpt
The low-affinity neurotrophin receptor p75 binds all neurotrophins with similar affinity. For elucidation of its function, mice bearing a null mutation in the p75 locus were generated. Examination of sympathetic innervation of target tissues revealed that pineal glands lacked innervation and sweat gland innervation was absent or reduced in particular footpads. The absence of adult innervation reflects the failure...
Topics
- Adrenergic Fibers
- Animals
- Axons
- Mice
- Mutation
- Pilocarpine
- Pineal Gland
- Receptors, Nerve Growth Factor
- Sweat Glands
- Sweating
- Vasoactive Intestinal Peptide