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Article

Dynamic interaction of S5 and S6 during voltage-controlled gating in a potassium channel.

The Journal of general physiology - 1 Aug 2001

Espinosa F, Fleischhauer R, McMahon A, Joho R H

Abstract excerpt

A gain-of-function mutation in the Caenorhabditis elegans exp-2 K(+)-channel gene is caused by a cysteine-to-tyrosine change (C480Y) in the sixth transmembrane segment of the channel (Davis, M.W., R. Fleischhauer, J.A. Dent, R.H. Joho, and L. Avery. 1999. Science. 286:2501-2504). In contrast to wild-type EXP-2 channels, homotetrameric C480Y mutant channels are open even at -160 mV, explaining the lethality of the...

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Identifiers

PMID: 11479343
DOI: 10.1085/jgp.118.2.157
PMCID: PMC2233824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamic interaction of S5 and S6 during voltage-controlled gating in a potassium channel.PMID 11479343Read ↗

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