Article
Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors.
Neurosurgery - 1 Aug 1993
Adams E F, Brockmeier S, Friedmann E, Roth M, Buchfelder M, Fahlbusch R
Abstract excerpt
A subgroup of growth hormone (GH)-secreting pituitary tumors carries somatic mutations within the gene coding for the alpha subunit of the stimulatory heterotrimeric guanosine 5'-triphosphate-binding protein, Gs alpha. These so-called gsp mutations result in constitutively activated Gs alpha and...
Topics
- Acromegaly
- Adenoma
- Adenylyl Cyclases
- Adult
- Cyclic AMP
- DNA, Neoplasm
- Female
- GTP-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Glucose Tolerance Test
- Humans
- Male
- Middle Aged
- Mitosis
- Mutation
- Pituitary Gland
- Pituitary Neoplasms
- Polymerase Chain Reaction