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Article

Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly.

Scientific reports - 9 Nov 2015

Martín-Rodríguez Juan F, Muñoz-Bravo Jose L, Ibañez-Costa Alejandro, Fernandez-Maza Laura, Balcerzyk Marcin, Leal-Campanario Rocío, Luque Raúl M, Castaño Justo P, Venegas-Moreno Eva, Soto-Moreno Alfonso, Leal-Cerro Alfonso, Cano David A

Abstract excerpt

Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels results in wide range of somatic, cardiovascular, endocrine, metabolic, and gastrointestinal morbidities. Subcutaneous implantation of the GH-secreting GC cell line in rats leads to the...

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Identifiers

PMID: 26549306
DOI: 10.1038/srep16298
PMCID: PMC4637865

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