Article
Mutations in the alpha subunit of the stimulatory regulatory protein of adenylyl cyclase (Gs) in human GH-secreting pituitary adenomas. Biochemical, clinical, and morphological aspects.
Pathology, research and practice - 1 Jun 1991
Spada A, Arosio M, Bassetti M, Vallar L, Clementi E, Bazzoni N
Abstract excerpt
Very recently a subset of human GH-secreting pituitary adenomas carrying a somatic mutation in the alpha subunit of the stimulatory regulatory protein of adenylyl cyclase (Gs) was identified. In all these tumors (Group 2; about 30% of all the GH secreting tumors studied) the alpha s cDNAs contained mutations; in 8 tumors mutations replaced Arginine 201 with either Cystein or Histidine while in the remaining...
Topics
- Adenoma
- Adenylyl Cyclases
- Genes
- Growth Hormone
- Humans
- Mutation
- Neoplasm Proteins
- Pituitary Neoplasms