Article
Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.
The Journal of clinical endocrinology and metabolism - 1 Sept 1992
Harris P E, Alexander J M, Bikkal H A, Hsu D W, Hedley-Whyte E T, Klibanski A, Jameson J L
Abstract excerpt
Activating mutations of the Gs alpha subunit have been identified in a subset of somatotroph adenomas. The mutant form of the Gs alpha subunit causes persistent activation of adenylyl cyclase and consequently results in high intracellular levels of cAMP. Because cAMP is known to stimulate the syn...
Topics
- Adenoma
- Base Sequence
- Cells, Cultured
- GTP-Binding Proteins
- Growth Hormone
- Humans
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- Tumor Cells, Cultured