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Article

Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.

The Journal of clinical endocrinology and metabolism - 1 Sept 1992

Harris P E, Alexander J M, Bikkal H A, Hsu D W, Hedley-Whyte E T, Klibanski A, Jameson J L

Abstract excerpt

Activating mutations of the Gs alpha subunit have been identified in a subset of somatotroph adenomas. The mutant form of the Gs alpha subunit causes persistent activation of adenylyl cyclase and consequently results in high intracellular levels of cAMP. Because cAMP is known to stimulate the synthesis of the glycoprotein hormone (GPH) alpha-subunit as well as GH, we examined somatotroph tumors with and without...

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PMID: 1517386
DOI: 10.1210/jcem.75.3.1517386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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