Article
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.
The Journal of clinical endocrinology and metabolism - 1 Dec 1990
Spada A, Arosio M, Bochicchio D, Bazzoni N, Vallar L, Bassetti M, Faglia G
Abstract excerpt
Somatic mutations in the alpha-chain (alpha s) of the stimulatory regulatory protein of adenylyl cyclase (Gs) causing constitutive activation of the enzyme have been identified in a subset of human GH-secreting pituitary adenomas. This study reports on the differences between acromegalic patients bearing tumors without (group 1; n = 51) or with (group 2; n = 29) this alteration. No difference in age, sex,...
Topics
- Acromegaly
- Adenoma
- Adenylyl Cyclases
- Adolescent
- Adult
- Aged
- Cytoplasmic Granules
- Dopamine
- Endoplasmic Reticulum
- Enzyme Activation
- Female