Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.

doi:10.1210/jcem-71-6-1416

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Article

Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.

The Journal of clinical endocrinology and metabolism - 1 Dec 1990

Landis C A, Harsh G, Lyons J, Davis R L, McCormick F, Bourne H R

Abstract excerpt

Activating mutations in the gene for the alpha-chain of Gs, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the...

Topics

Acromegaly
Adenoma
Adult
Aged
Female
GTP-Binding Proteins
Glucose
Growth Hormone
Humans
Hyperprolactinemia
Male
Middle Aged
Mutation
Pituitary Neoplasms

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