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Article

Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.

The Journal of clinical endocrinology and metabolism - 1 Dec 1990

Landis C A, Harsh G, Lyons J, Davis R L, McCormick F, Bourne H R

Abstract excerpt

Activating mutations in the gene for the alpha-chain of Gs, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the presence of the activating mutations. We also reviewed the clinical charts of the patients from whom the tumors were...

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PMID: 2121775
DOI: 10.1210/jcem-71-6-1416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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