Article
Comparison of the mechanism of action and resistance of two new fluoroquinolones, rufloxacin and MF961 with those of ofloxacin and fleroxacin in gram-negative and gram-positive bacteria.
The Journal of antimicrobial chemotherapy - 1 Jun 1993
Piddock L J, Panchal S, Norte V
Abstract excerpt
For rufloxacin MF961, ofloxacin and fleroxacin the inhibition of DNA synthesis, intracellular accumulation, optimum bactericidal concentration (OBC) and killing kinetics at the OBC for Enterobacteriaceae, Pseudomonas aeruginosa and staphylococci and induction of recA in Escherichia coli were determined. All agents had good activity against all the strains and inhibited DNA synthesis by 50% at concentrations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.