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Article

Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria.

Antimicrobial agents and chemotherapy - 1 Nov 1991

Piddock L J, Zhu M

Abstract excerpt

The inhibition of DNA synthesis by sparfloxacin; accumulation of sparfloxacin into members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci; induction of recA in Escherichia coli; and the optimum bactericidal concentration (OBC) were measured, and killing kinetics at the OBC were estimated. The OBC and maximum recA-inducing concentration in E. coli were both 1 microgram of sparfloxacin...

Topics

Anti-Bacterial Agents
Ciprofloxacin
DNA Probes
DNA, Bacterial
Drug Resistance, Microbial
Enterobacteriaceae
Fluoroquinolones
Gram-Negative Bacteria
Gram-Positive Bacteria
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pseudomonas aeruginosa

Quinolones

Source

Open in PubMed Open full text

Identifiers

PMID: 1666499
DOI: 10.1128/AAC.35.11.2423
PMCID: PMC245397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1666499-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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