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Article

Activity of and resistance to moxifloxacin in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Apr 2003

Ince Dilek, Zhang Xiamei, Hooper David C

Abstract excerpt

Moxifloxacin has enhanced potency against Staphylococcus aureus, lower propensity to select for resistant mutants, and higher bactericidal activity against highly resistant strains than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred target in vivo.

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Identifiers

PMID: 12654680
DOI: 10.1128/AAC.47.4.1410-1415.2003
PMCID: PMC152517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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