Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus.

doi:10.1093/jac/41.4.481

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Article

Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus.

The Journal of antimicrobial chemotherapy - 1 Apr 1998

Schmitz F J, Hofmann B, Hansen B, Scheuring S, Lückefahr M, Klootwijk M, Verhoef J, Fluit A, Heinz H P, Köhrer K, Jones M E

Abstract excerpt

The in-vitro activities of five fluoroquinolones were tested against 70 ciprofloxacin-resistant and 46 ciprofloxacin-susceptible unrelated isolates of Staphylococcus aureus. All 116 S. aureus isolates were studied for the presence of mutations in the grl and gyr loci. The order of efficacy of the...

Topics

Anti-Infective Agents
Ciprofloxacin
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II
DNA, Bacterial
Drug Resistance, Microbial
Humans
Microbial Sensitivity Tests
Mutation
Polymerase Chain Reaction
Staphylococcus aureus

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Identifiers

PMID: 9598779
DOI: 10.1093/jac/41.4.481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9598779-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.