Article
Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro.
Antimicrobial agents and chemotherapy - 1 Dec 1996
Gootz T D, Zaniewski R, Haskell S, Schmieder B, Tankovic J, Girard D, Courvalin P, Polzer R J
Abstract excerpt
The MICs of trovafloxacin, ciprofloxacin, ofloxacin, and sparfloxacin at which 90% of isolates are inhibited for 55 isolates of pneumococci were 0.125, 1, 4, and 0.5 microgram/ml, respectively. Resistant mutants of two susceptible isolates were selected in a stepwise fashion on agar containing ci...
Topics
- Animals
- Anti-Infective Agents
- Ciprofloxacin
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Gene Amplification
- Genes, Bacterial
- Mice
- Microbial Sensitivity Tests
- Mutation
- Naphthyridines
- Pneumonia, Pneumococcal