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Article

Impact of recA on levofloxacin exposure-related resistance development.

Antimicrobial agents and chemotherapy - 1 Oct 2010

Singh Renu, Ledesma Kimberly R, Chang Kai-Tai, Tam Vincent H

Abstract excerpt

Genetic mutations are one of the major mechanisms by which bacteria acquire drug resistance. One of the known mechanisms for inducing mutations is the SOS response system. We investigated the effect of disrupting recA, an inducer of the SOS response, on resistance development using an in vitro hollow-fiber infection model. A clinical Staphylococcus aureus isolate and a laboratory wild-type strain of Escherichia...

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Identifiers

PMID: 20660686
DOI: 10.1128/AAC.00168-10
PMCID: PMC2944593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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