Article
Altered properties of the herpes simplex virus ICP8 DNA-binding protein in cells infected with ICP27 mutant viruses.
Virology - 1 Sept 1993
Curtin K D, Knipe D M
Abstract excerpt
Herpes simplex virus mutant strains that fail to encode a functional ICP27 polypeptide show a reduction in their ability to replicate viral DNA compared to wild-type virus. To define the nature of this defect, we examined the formation of viral DNA replication structures in the nucleus of cells i...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Cell Cycle
- Cell Line
- DNA Replication
- DNA, Viral
- DNA-Binding Proteins
- Fluorescent Antibody Technique
- Genetic Complementation Test
- Immediate-Early Proteins
- Mutation
- Simplexvirus
- Trans-Activators
- Vero Cells
- Viral Proteins
- Virus Replication