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Article

Altered properties of the herpes simplex virus ICP8 DNA-binding protein in cells infected with ICP27 mutant viruses.

Virology - 1 Sept 1993

Curtin K D, Knipe D M

Abstract excerpt

Herpes simplex virus mutant strains that fail to encode a functional ICP27 polypeptide show a reduction in their ability to replicate viral DNA compared to wild-type virus. To define the nature of this defect, we examined the formation of viral DNA replication structures in the nucleus of cells infected with these mutant viruses. In cells infected with wild type HSV, viral DNA replication occurs in replication...

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Identifiers

PMID: 8395110
DOI: 10.1006/viro.1993.1449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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