Article
A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: effects on DNA replication and late gene expression.
Journal of virology - 1 Nov 2000
McNamee E E, Taylor T J, Knipe D M
Abstract excerpt
The d105 dominant-negative mutant form of the herpes simplex virus 1 (HSV-1) single-stranded DNA-binding protein, ICP8 (d105 ICP8), inhibits wild-type viral replication, and it blocks both viral DNA replication and late gene transcription, although to different degrees (M. Gao and D. M. Knipe, J. Virol. 65:2666-2675, 1991; Y. M. Chen and D. M. Knipe, Virology 221:281-290, 1996). We demonstrate here that this...
Topics
- Animals
- Cell Line, Transformed
- Cell Nucleus
- Cell Transformation, Viral
- Chlorocebus aethiops
- DNA Replication
- DNA-Binding Proteins
- Gene Expression
- Herpesvirus 1, Human
- Models, Biological
- Mutation
- Vero Cells
- Viral Proteins
- Virus Replication