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The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres

17 Jun 2008

Abstract excerpt

The UL15, UL28 and UL33 proteins of herpes simplex virus type 1 (HSV-1) are thought to comprise a terminase complex responsible for cleavage and packaging of the viral genome into pre-assembled capsids. Immunofluorescence studies confirmed that shortly after infection with wild-type HSV-1 these three proteins localize to viral DNA replication compartments within the nucleus, identified by the presence of the...

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PMID: 18559942
DOI: 10.1099/vir.0.2008/000448-0

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The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centresPMID 18559942Read ↗

Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28.Semantic proximity Read ↗

Genetic analysis of the UL 15 gene locus for the putative terminase of herpes simplex virus type 1.Semantic proximity Read ↗

Isolation and characterization of the herpes simplex virus 1 terminase complex.Semantic proximity Read ↗

The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA.Semantic proximity Read ↗

Interaction of the herpes simplex virus type 1 packaging protein UL15 with full-length and deleted forms of the UL28 proteinSemantic proximity Read ↗

Herpes simplex virus DNA cleavage and packaging proteins associate with the procapsid prior to its maturation.Semantic proximity Read ↗

Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins.Semantic proximity Read ↗

Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1.Semantic proximity Read ↗

The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 proteinSemantic proximity Read ↗

Linker insertion mutations in the herpes simplex virus type 1 UL28 gene: effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation.Semantic proximity Read ↗

ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.Semantic proximity Read ↗

Herpes simplex virus replication compartments can form by coalescence of smaller compartments.Semantic proximity Read ↗

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