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Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells

11 Oct 2016

Abstract excerpt

We have previously shown that clusters of guanine quadruplex (G4) structures can form in the human herpes simplex-1 (HSV-1) genome. Here we used immunofluorescence and immune-electron microscopy with a G4-specific monoclonal antibody to visualize G4 structures in HSV-1 infected cells. We found that G4 formation and localization within the cells was virus cycle dependent: viral G4s peaked at the time of viral DNA...

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PMID: 27794039
DOI: 10.1093/nar/gkw968

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