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Article

Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis.

Journal of virology - 1 Dec 1990

Goodrich L D, Schaffer P A, Dorsky D I, Crumpacker C S, Parris D S

Abstract excerpt

Using indirect immunofluorescence, well-characterized monoclonal and polyclonal antibodies, and temperature-sensitive (ts) mutants of herpes simplex virus type 1, we demonstrated that the 65-kilodalton DNA-binding protein (65KDBP), the major DNA-binding protein (infected cell polypeptide 8 [ICP8]), and the viral DNA polymerase (Pol) colocalize to replication compartments in the nuclei of infected cells under...

Topics

Animals
Antibodies, Monoclonal
DNA Replication
DNA-Binding Proteins
DNA-Directed DNA Polymerase
Fluorescent Antibody Technique
Molecular Weight
Mutation
Phosphonoacetic Acid
Simplexvirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vero Cells

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Identifiers

PMID: 2173766
DOI: 10.1128/JVI.64.12.5738-5749.1990
PMCID: PMC248718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2173766-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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